I thought it might be related to the fact I have two Wiimotes - anyone else having a similar problem? My thought process was that I had tried to pair both and had confused Remote Buddy.

Pressing buttons 1 & 2 has never worked, I'm interested in what others have to say. Red sync button works inconsistently for me, maybe I'm pressing it too early or too late.

Love the software, keep up the great work, just want to get the pairing issue figured out. 
Cheers, 
Ben