profiles are organized this way:

- there's the default profile (=> whose layout you determine with the 
option at Preferences > General > Menu Structure Style) 
- user-defined profile(s)

Which profile is used is determined by your selection in Preferences > 
Menu.

Thus, if you choose your a user-defined profile, that one will also be 
used - regardless of what you set in Preferences > General. That 
option only determines which style is used for the default profile. 
The default profile has to be selected to be used.

Regarding your second question: 
Right now, duplicating or creating pre-populated profiles is not a 
feature of Remote Buddy. This is on the ToDo list however.

The next version will bring a lot of improvements in this area.

Best regards, 
Felix