If you could provide me with more info, this would be helpful, namely:

- which version of OS X you are using

- which version of Remote Buddy you are using

- whether you have the kernel extension installed

- whether you have paired your remote with the Mac (=> please note 
that only the remote you have paired your Mac with can be used to wake 
up your Mac. If you previously paired your Mac with a remote and then 
make use of Remote Buddy's support for multiple remotes - which 
ignores the pairing info - you can put your Mac to sleep with Remote 
Buddy using a remote other than the one you paired, but you'll only be 
able to wake up your Mac again, if you are using the remote that you 
have paired)

- if you have paired your Mac with the remote: if the problem persists 
if you unpaired it

Best regards, 
Felix