Keep in mind the Keyspan RF for Front Row essentially appears like a 
USB keyboard to the system.

So it's possible that during boot time, the default keyboard driver 
claims the Keyspan RF for FR before Remote Buddy's driver appears on 
the scene. On a reinsert, Remote Buddy's driver is there and will win 
the matching for the driver.

Here's an easy experiment that'll tell me whether this is the case:

Next time you experiene this, open Remote Buddy's Setup Wizard and 
choose to Install or Testdrive the driver. Please let me know if, 
after that, the Keyspan RF for FR turns up in your list of remotes - 
and whether it prompted you to Reboot.

Thanks in advance.

Best regards, 
Felix