I have recently seen some reports like yours that eventually all 
traced back to

1) the use of badly written ApplicationEnhancer (APE) modules or 
InputManagers that injected code into Remote Buddy and through the 
misue of Core Audio in that injected code, deadlocked Remote Buddy's 
main runloop.

If you have APE installed, please either put Remote Buddy on its list 
of apps to exclude from injected code or - better - uninstall APE (=> http://support.apple.com/kb/TS1545 
) and/or InputManagers you may be using. Then reboot to make sure no 
remains are left over in memory.

2) the use of ringtones in iTunes. Since iTunes 7.6.x, iTunes carries 
a bug that freezes apps that use its AppleScript API in absolutely 
standard ways. Removing the ringtones from the library instantly fixes 
the problem (=> more info available in the FAQ and the forum).

If you experience freezes even after excluding 1) and 2), please 
create an "Analyze-log" using Activity Monitor.app's "Analyze" 
function and send it - along with a System Profile - to the info 
address as found in the site's Imprint.

Best regards, 
Felix Schwarz