Yes, you can use multiple Wii Remotes with Remote Buddy concurrently 
and also map them differently. I've extensively tested it with two Wii 
Remotes. The only real limit to the number of Wii Remotes you can use 
at the same time is defined by the Bluetooth standard. So if you want 
to use more than, say, four at the same time, please keep these 
technical limitations in mind.

Best regards, 
Felix Schwarz 

Thanks for your reply. Can you describe how do you pair 2 wii remotes together ? I've tried to pair up 2 remotes, but the application just can't seem to detect the second remote.

Regards,

Lennard 

Thanks for asking.

Setup needs to be run through for each remote:

1) Open the Setup Wizard and use it to pair with remote 1. 
2) Click on the "Pair another remote" button or open the Setup Wizard 
once again. 
3) Now use the Setup Wizard to pair with remote 2. 
4) From now on, pressing 1+2 together on either remote will connect it 
to your computer.

Best regards, 
Felix Schwarz 

That's what I did...but somehow the software is not picking up the second remote. Any other troubleshooting ideas ?

Lennard 

Thanks, it's working now. I guess it took a little longer to pair the second device :-) 

Best regards, 
Felix Schwarz