This posting is older than 6 months and can contain outdated information.
I am trying to set up Remote Buddy and have been extremely pleased with the product.  The one challenge I am having is the Plus and Minus Buttons in Front Row.  I am using a Harmony Remote with the Plex configuration (Multiple Apple Virtual remotes).  I am not running Plex on my machine.  In Front Row when I click the + and - buttons, The first click performs a single movement up or down.  Every subsequent click results in two movements up or down.  When running EyeTV I have not noticed this behavior.  I mapped the buttons originally to the + and - buttons of the apple remote and then changed them to the up and down arrows on the virtual keyboard (with a single click).  In both configurations I get the same error.  I saw a previous post describing a similar issue with Plex, but Felix seemed to beleive that the problem was within Plex.  Since I have not installed Plex (yet) I am wondering if this is a Remote Buddy issue.
Thanks for your time.
Configuration:
Early 2009 Mac Mini 
Leopard 10.5.8 then Upgraded to Snow Leopard 10.6.2 (Observed behavior in both configurations)