This posting is older than 6 months and can contain outdated information.
Thanks for asking.
All changes you make to settings in Remote Buddy take immediate 
effect. There's no need to reboot.
Please recheck you have really chosen the correct actions for the 
respective buttons in the global mappings table exactly as shown in 
the screenshot. If you need further assistance, please file a support 
inquiry (should you not already have done so), so we can share 
screenshots, etc.
Best regards, 
Felix Schwarz