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Hello Felix,
Thanks for your reply!
I am using OS X Yosemite, 10.10. The Plex app is "Plex Home Theatre", in version 1.3.1.409-5989c392.
Remote Buddy Express is in version 1.26.1. Candler is in version 1.12, driver 1.24.
I tried several configurations, including setting each button to not do any actions in the iTunes behavior and the global settings.
What else can I try? Or what can I do to help you help me :)
Thanks again, cheers,
Sébastien