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This is going to sound crazy, but Remote Buddy (v1.16.6) is causing a per-flow rate limit on SMB transfers to my Drobo FS. I noticed that my Mac Minis were having a really hard time streaming video from my Drobo FS (I have two, both configured with Remote Buddy). I spent all day troubleshooting. I replaced Ethernet cables, wired the Mac Minis direct to the Drobo FS, performed iPerf tests between my two Mac Minis and my iMac, and transfered files between machines using SMB. Machine to machine transfers worked great. SMB transfers from my Drobo to my iMac worked great. But I couldn't get anything over 2MBps (yes, MBytes/sec) to my mac minis. So, I start turning things off on the Mac Minis. It turns out, as soon as I turn off Remote Buddy, file transfers shoot up to 35MBps (280Mbps). This is easily duplicable.
The really strange thing is that it's not an overall bandwidth throttling. It's a per-flow throttling. When I select 10 files at once and drag them from my Drobo to my Mac Mini, the files are transferred serially and the transfer only gets 1-2MBps. If I drag the files one-by-one from my Drobo to my Mac Mini, *each* file gets 1-2MBps of bandwidth and the overall bandwidth goes up to a ceiling of about 35MBps.
I can't think of any reason why an IR utility would affect data transfer, or why that utility is only affecting SMB data transfers to my Drobo, but not to other machines on my network. Anyway, this drove me nuts for a good 5 hours today, so posting in case others have seen similar problems. Hopefully the devs know what to do with it.