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Thanks for the feedback.
OSX Maverick 10.9.4 with remote buddy 1.25.2
Mavericks added App Nap, which can lead to lagging issues like the one you described.
Remote Buddy itself is no longer affected by App Nap since version 1.24.2 released last November.
However, other apps that weren't adapted to App Nap may still be.
If in doubt, you can select an app that causes issues in Finder, open the "Get Info" dialog for it and select "Disable App Nap" for that app. OS X should respect that setting _after_ the next launch of the respective application.
Which version of Plex are you using?
Which actions do you use to control Plex? Are you using Remote Buddy's Plex Behaviour actions or are you also using Remote Buddy's Virtual Remote?
Now its getting worst. I unpaired my remote and now when I want to pair it again, its just not working. I am using this guide https://www.iospirit.com/blog/article/184/HowTo-Set-up-the-Logitech-Harmony-Smart-Control-with-Remote-Buddy-and-control-100-Mac-apps-with-it/
It worked like a charm the first time but now the harmony app wont pair.
Since the Smart Hub can emulate several different Bluetooth devices but the OS X Bluetooth stack optimizes for each device only being, well, one device, there can be conflicts between what OS X caches about a Bluetooth device - and what a Bluetooth device like the Smart Hub tries to be at a given time.
To avoid running into issues with the OS X Bluetooth stack's cache, please only pair the Harmony Hub with your Mac in one role: as a PS3 Remote. Pairing it as a keyboard or other device at the same time will lead to problems with what OS X has cached about the device.
To remove bogus data from the cache, try this:
1) delete the device from both Remote Buddy (Hardware > Bluetooth Receiver) and OS X (System Preferences > Bluetooth).
2) turn off Bluetooth
3) reboot
4) turn on Bluetooth
5) pair as per step 2 in https://www.iospirit.com/blog/article/184/-/
Tried with a wii remote and its working fine
Just out of curiosity: was that a real Wii Remote - or the Harmony Hub emulating a Wii Remote?
Best regards,
Felix Schwarz